Squamous cell carcinoma - Karsinom Selil Squamous
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ReferencesSquamous cell carcinoma (SCC) se dezyèm kansè po ki pi komen Ozetazini, apre basal cell carcinoma. Anjeneral, li kòmanse kòm blesi prekansè ki rele actinic keratosis, epi li ka pwopaje nan lòt pati kò a. Kòz prensipal la se ekspoze a radyasyon iltravyolèt (UV) ki soti nan solèy la, ki akimile sou tan. Tretman anjeneral enplike retire chirijikal, espesyalman pou SCC sou tèt ak kou. Terapi radyasyon se yon opsyon pou pasyan ki pi gran oswa pou moun ki pa ka fè operasyon. Imunosuppresyon ogmante risk pou SCC. Malgre ke li ra, SCC ka gaye, espesyalman nan pasyan ki gen sistèm iminitè febli. Itilizasyon regilye pwoteksyon solèy enpòtan pou moun ki gen SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) se dezyèm kansè ki pi komen pami moun, epi kantite li yo ap ogmante. Malgre ke CSCC anjeneral montre yon konpòtman benign klinik, li ka gaye tou de lokalman ak ale nan lòt pati kò a. Syantis yo te idantifye chemen espesifik ki enplike nan devlopman CSCC, ki mennen nan nouvo tretman. Gwo kantite mitasyon ak risk ki ogmante nan pasyan imunosupprime yo te pouse devlopman imunoterapi. Revizyon sa a egzamine rasin jenetik CSCC ak dènye tretman ki vize molekil espesifik ak sistèm iminitè a.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Dyagnostik ak Tretman
#Dermoscopy
#Skin biopsy